Research Articles
A Sweet Trap for Rogue Cancer Cells: Starving Tumors of Sugar Triggers Self-Destruction
Discover how glucose restriction induces degradation of mutant p53 proteins via selective autophagy, offering new cancer therapy approaches.
The Cancer Hijacker: How a Splice Variant Tricks Our Cellular Machinery to Drive Liver Cancer
Discover how the novel ADRM1/Rpn13 spliced isoform promotes hepatocellular carcinoma through selective degradation of tumor suppressor p53
The Cell's Master Switch-Flipper: Unraveling the Secrets of USP7
Explore the fascinating role of USP7 deubiquitinase in cellular regulation, cancer mechanisms, and therapeutic potential.
The Cellular Tug-of-War: How a Brain Cell Protein Dodges Cancer-Fighting Bullets
Discover how Olig2 SUMOylation protects cells from genotoxic damage by antagonizing p53 gene targeting in this engaging scientific exploration.
The Unlikely Betrayal: How a DNA Repairman Helps Deactivate a Cancer-Fighting Hero
Discover how XPC protein collaborates with MDM2 to degrade p53 tumor suppressor, revealing new insights into cancer mechanisms and potential therapies.
Cellular Switchboards: How Protein Modifications Rewire Leukemia Cells and Silence Tumor Suppressors
Explore how ubiquitin-like modifications and p53 NEDDylation at lysine 120 impact chronic lymphocytic leukemia progression and treatment.
The Cell's Double Agent: How a Stress Protein Switches Sides to Fight Cancer
Discover how the stress protein ATF3 acts as a molecular double agent, stabilizing p53 by competing with MDM2 to fight cancer development.
The Guardian's Betrayal: When the Body's Cancer Defense Turns Rogue
Explore how mutations in the MDM2 protein can subvert the body's natural cancer defenses and contribute to tumor development.
The Unlikely Guardian: How a Cellular Enzyme Switches Sides to Protect Us From Cancer
Discover how the Otub1 enzyme stabilizes p53 through monoubiquitination, revealing a novel cancer protection mechanism
The Cellular Betrayal: How a Rogue Protein Hijacks Our Body's Cancer Defense
Discover how the SS18-SSX1 oncoprotein promotes cancer by hijacking the p53 tumor suppressor pathway through enhanced HDM2 stability.